Anju Pradhan
B.P.Koirala Institute of Health Sciences, Nepal
Title: Role of cell blocks preparation in fine needle aspiration in malignant lesions
Biography
Biography: Anju Pradhan
Abstract
Background and Objectives
In diagnosing a neoplastic lesion from any area, fine needle aspiration cytology can provide a level, as to whether the lesion is benign or malignant. Cell block preparation in a way will mimic the histopathological sections, thus help in sub classifying various neoplastic lesions as well. The objectives of this research was to evaluate the diagnostic utility of cell block in fine needle aspiration of malignant lesions.
Materials and Methods
This was a prospective hospital based study conducted in the department of pathology, BPKIHS over a period of 1 year. A total of 41 cases who were suspected or diagnosed as cases of malignancy in FNAs smear of whom cell block and histopathology specimens, available were included in this study.
Results
Smear were diagnostic in 93% of cases while Cell block were diagnostic in 80% of cases Smear supplemented by Cell block improved diagnosis which reached to 98%.The cell block diagnosis confirmed that of smear diagnosis in 56% cases. It established specific diagnosis in 24% cases and hence contributed especially in cases where smears were non-diagnostic. Therefore, CB were found to be superior to smears in these cases. The cell block was non-confirmatory in 20% cases. The main non-confirmatory nature of cell block was mainly due to the non-diagnostic yield of cell block.
Conclusion
This study concludes that Cell Blocks have a synergistic effect on Conventional Smear diagnosis. In selected cases where CS falls into suspicious for malignancy category, Cell Blocks can render a specific diagnosis.
Keywords: Cell block, Malignant lesion, Smear diagnosis