Pyakurel D
B.P. Koirala Institute of Health Sciences, Nepal
Title: A study on microvascular density in breast carcinoma
Biography
Biography: Pyakurel D
Abstract
BACKGROUND: Breast Cancer is the most frequent neoplasm causing death in women between 35-55 years. Of the prognostic indicators existing for breast cancer, axillary lymph node status has been regarded as the most important one. 20-30% of all lymph-node-negative patients will still develop a recurrence of the disease within 10 years of initial treatment. Therefore, a new prognostic marker that could identify patients at high risk of tumor recurrence more accurately would be of great value, one potential indicator is tumor-induced angiogenesis.
OBJECTIVE: To determine semi quantitative micro vascular density in breast lesions and to find its association with prognostic factors as tumor size, axillary lymph node status, tumor type, histological grade and vascular invasion.
MATERIAL AND METHODS: Thirty five cases were included in the study. Angiogenesis was estimated by determining micro vessel counting after immune staining the paraffin embedded tissue sections using anti-CD34 antibody.
RESULT: Age of the patients ranged from 25 to 80 years with a mean age of 45.48 years. Most of the cases were infiltrating ductal carcinoma comprising of 33 cases (94.28%). Three (3) cases (9.10%) showed vascular invasion by the tumor. Majority showed (63.64%) vessel count of less than 200 per 10 high power fields.
CONCLUSION: Micro vascular density positively correlated with size of the tumor, lymph nodes involved by the tumor and Nottingham prognostic index. Micro vascular density and histological grade showed near significant relation. Micro vascular density although positively correlated do not have significant relationship with vascular invasion in this study.