Rabia butt
Chughtai Lab, Pakistan
Title: Comparison Of E-Cadherin/Î’eta-Catenin Complex In Inflammatory Nasal Polyps, Sinonasal Inverted Papilloma & Nasopharyngeal Carcinoma
Biography
Biography: Rabia butt
Abstract
Cell-cell junctions are important to maintain cell and tissue polarity and integrity. E-cadherin/beta-catenin complex plays significant role in maintaining epithelial integrity. Disruption of this complex not only affects the adhesive properties of cells but also activates the Wnt signaling pathway, which is observed in many malignancies and fibrotic disorders. We conducted this study to compare the dysregulation of this complex in inflammatory nasal polyps (INP), sinonasal inverted papillomas (SIP) and nasopharyngeal carcinomas (NPC). A cross-sectional study was conducted on 82 cases, retrieved from archives of Chughtais Lab. Lahore, out of which 68 cases were of INPs, 9 cases were of SIP and 5 cases were of NPC using non-probabilty consecutive sampling technique. Our study showed dysregulation of this complex in 19 (27.9%) cases of INPs, which were predominantly accompanied by fibrosis, 7 (77.8%) cases of SIP and in all 5 (100%) cases of NPC. Nuclear staining was evident in all 5 cases of NPC. Our study concluded that this complex is dysregulated in INPs associated with fibrosis and in neoplastic disorders. Dysregulation of E-cadherin/beta-catenin complex may be involved in recurrence and malignant transformation of INP and SIP. Therefore close followup is required for such patients of INP and SIP, to prevent recurrence and progression of disease.