Minh Bui Huynh Quang
Pham Ngoc Thach University of Medicine, Viet Nam
Title: Expression of EPCAM in Hepatocellular Carcinoma
Biography
Biography: Minh Bui Huynh Quang
Abstract
Objectives: (1) The aim of this study was to evaluate the expression of EpCAM (Epithelial Cell Adhesion Molecule) in Hepatocellular carcinoma (HCC) and correlated the results with pathologic characteristics.
Methods: Cross sectional study. Target: 100 patients were diagnosed with HCC between 2010 and 2013 at the Department of Pathology, University Medical Center HCMC.
Results: EpCAM expression was observed in 19% of the HCCs (19/100). EpCAM expression in HCC was only significantly correlated with histological grading of HCC. However, for survival analysis, there was no statistically significant correlation with overall survival was detected in this study, only 4 factors: architectural patterns, cytological variants, groups of tumor size, microvascular invasion had a significant impact on overall survival.
Conclusion: A small subpopulation of cancer stem cells have been identified by EpCAM expression. EpCAM has been demonstrated the potential role in opening up novel pathways and therapeutic strategies as an effective immunotherapy – targeted strategy for patients with HCC.
Key words: EpCAM, Hepatocellular carcinoma,